Renoprival Hernolysis and Its Prevention by Renal Tissue
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چکیده
B ILATERAL NEPIIRECTOMY of the dog and rabbit is associated with a hemolytic state as demonstrated by a rapid decline in red blood cell volume in the absence of hemorrhage which, at the same time, is associated with elevation of serum bilirubin ( mainly “indirect” type ) , stool urobilinogen and serum iron, and siderosis of liver, spleen and lymph nodes.”2 While renoprival hemolysis progresses, the erythrocytes display a lowered reduced glutathione content, a reduction in glucose utilization and a decrement in inorganic phosphate flux.3 The erythrocytes appear to be removed from the circulation primarily by reticuloendothelial cells as indicated by erythrophagocytosis which is most evident in lymph nodes.4 The present experiments were designed to study renoprival hemolysis and its prevention by renal tissue through the means of the radiochromium method for evaluation of the erythrocytic life span. In addition, certain general characteristics of the erythrocyte during renoprival hemolysis were appraised. The main question tested concerned itself with whether renal tissue per se was related to the survival of canine erythrocytes in vivo. Part of the material presented has appeared in abstract form.5’6
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Renoprival Hernolysis and Its Prevention by Renal Tissue
B ILATERAL NEPIIRECTOMY of the dog and rabbit is associated with a hemolytic state as demonstrated by a rapid decline in red blood cell volume in the absence of hemorrhage which, at the same time, is associated with elevation of serum bilirubin ( mainly “indirect” type ) , stool urobilinogen and serum iron, and siderosis of liver, spleen and lymph nodes.”2 While renoprival hemolysis progresses,...
متن کاملRenoprival Hemolysis and Its Prevention by Renal Tissue.
B ILATERAL NEPIIRECTOMY of the dog and rabbit is associated with a hemolytic state as demonstrated by a rapid decline in red blood cell volume in the absence of hemorrhage which, at the same time, is associated with elevation of serum bilirubin ( mainly “indirect” type ) , stool urobilinogen and serum iron, and siderosis of liver, spleen and lymph nodes.”2 While renoprival hemolysis progresses,...
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• Nephreetomized dogs given sodium parenterally and protein by diet develop acute hypertensive cardiovascular disease.' Protection, against acute renoprival hypertension of this type has been demonstrated for (a) intact renal tissue as exemplified by ureterocaval anastomosis, (b) autoexplanation of whole kidney or renal medulla, and (c) a crude extract of renal medulla. Both medullorenal extrac...
متن کاملReduction of experimental renal hypertension by kidney perfusion.
A s AN introduction to a discussion of the blood pressure reducing function of the kidneys, I want to review what I believe to be the basic facts of renoprival hypertension. We have compared the average increase in blood pressure in groups of dogs treated in certain ways after bilateral nephrectomy. The overhydrated dogs developed renoprival hypertension more rapidly than the others, but all do...
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